WHO: Rotavirus vaccination should be included in all national immunization programs

6/8/2009

GENEVA The World Health Organization on Friday recommended that rotavirus vaccination be included in all national immunization programs in order to provide protection against a virus that is responsible for more than 500,000 diarrheal deaths and 2 million hospitalizations annually among children.

“This is a tremendous milestone in ensuring that vaccines against the most common cause of lethal diarrhea reach the children who need them most,” stated Thomas Cherian, coordinator of the expanded program on inmunization, WHO Department of Immunization, Vaccines and Biologicals.

More than 85% of these deaths occur in developing countries in Africa and Asia, WHO stated. This new policy will help ensure access to rotavirus vaccines in the world’s poorest countries.

The new recommendation by the WHO's Strategic Advisory Group of Experts, extends an earlier recommendation made in 2005 on vaccination in the Americas and Europe, where clinical trials had demonstrated safety and efficacy in low- and intermediate-mortality populations. New data from clinical trials which evaluated vaccine efficacy in countries with high child mortality has led to the recommendation for global use of the vaccine. This is reported in the Weekly Epidemiological Review published June 5.

The GAVI Alliance, vaccine manufacturers and the public health community made an unprecedented commitment to understand how these vaccines would work in developing-world conditions. The clinical trial, funded in part by GAVI and conducted by PATH, WHO, GlaxoSmithKline and research institutions in high-mortality, low-socioeconomic settings of South Africa and Malawi, found that rotavirus vaccine significantly reduced severe diarrhea episodes due to rotavirus.

In 2006, the GAVI Alliance added rotavirus vaccines to its portfolio of vaccines for which it provides financial support to developing countries, underscoring GAVI’s commitment to reduce the traditional 15- to 20-year lag between the introduction of new vaccines in wealthy countries and their availability in the developing world.

“The GAVI Alliance welcomes this exciting recommendation,” stated GAVI CEO Julian Lob-Levyt. “It represents another important step in our ability to achieve significant impact on under-five deaths in the world’s poorest communities and make progress towards the Millennium Development Goals. We are extremely excited about the potential to offer African and Asian countries funding to introduce rotavirus vaccines.”

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