Makucell launches anti-aging skin care brand with innovative new technology


Makucell — a regenerative biotechnology company that develops, manufactures and distributes anti-aging skin care — has unveiled its new Renewnt brand. The product line uses a proprietary ingredient known as Asymmtate, which the company said energizes the skin's stem cells, encouraging youthful cell behavior for firmer and smoother skin.

Asymmtate technology was developed at University of Southern California's Keck School of Medicine and transferred to Makucell's Renewnt skin care line. The technology encourages optimal signaling in the body's Wnt signal pathway, thereby stimulating the skin stem cells to begin the process leading to keratinocytes, fibroblasts and other dermal cells, which produce collagen, elastic tissue and substances in the supporting skin matrix.

According to the company, Renewnt products:

  • Penetrate into viable skin;

  • Are not irritating or sensitizing;

  • Show measurable up-regulation of genes that express skin structural proteins with simultaneous down-regulation of inflammatory genes in gene expression analysis; and

  • Perform well in clinical studies. Skin shows smoothing, plumping and an improvement in texture after as little as four weeks.

“Makucell is committed to supporting our claims with results from controlled, blinded studies,” explains Dr. Mark Dahl, Makucell chief medical officer and former president of the American Academy of Dermatology. “We conducted standard industry safety tests, and the results were universally positive; Renewnt products were well tolerated with no adverse effects or safety issues. A combination of clinical trials and in vitro gene expression studies from treated biopsied skin continues to corroborate the aesthetic effects noted in the clinic.”

Makucell's current Renewnt skin care products include:

  • Renewnt for Hydration, a day and night facial moisturizer for a more youthful-looking appearance;

  • Renewnt for Strength, for the dry, thinning skin on hands and forearms to seal in moisture, repair the signs of aging and restore the essential skin barrier;

  • Renewnt for Firmness, a neck and décolletage cream hydrates and improves elasticity, reduces wrinkles and roughness, and visibly increases firmness; and

  • Renewnt for Brightness, a serum to address irregular skin pigmentation and sun damage to lighten and even skin color.

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